Seth MacFarlane is an American actor, animator, writer, producer, director, comedian, and singer. He is the creator of the television series Family Guy, American Dad!, and The Cleveland Show. MacFarlane has also directed and starred in films like Ted and A Million Ways to Die in the West.
This is based on winning 16 head-to-head matchups with other famous people, but also losing 10 head-to-head matchups.
Most recently Seth MacFarlane lost a matchup to Courteney Cox (#115) voted by someone from United States.